The basic argument for glucosamine is that it is naturally found in high concentrations in the connective tissues and cartilage of the human body. So by supplying the body with a ready supply of glucosamine, an amino monosaccharide, and an intermediate substrate needed for the synthesis of glycosaminoglycan and proteoglycans makes logical fish wife sense. After all it’s the glycosaminoglycan and proteoglycan components of cartilage which give cartilage its functional shock absorber properties. Supporters believe that glucosamine’s positive benefits are due to its role in supporting the production of proteoglycan, and it is in this role as a cartilage building block that it believed relevant to the treatment of osteoarthritis (the gradual deterioration of the articular cartilage lining) and general knee pain. (more…)